PUBLICATION

Integration of anterior neural plate patterning and morphogenesis by the Wnt signaling pathway

Authors
Cavodeassi, F.
ID
ZDB-PUB-131113-4
Date
2014
Source
Developmental Neurobiology   74(8): 759-71 (Review)
Registered Authors
Cavodeassi, Florencia
Keywords
Wnts, forebrain, anterior neural plate, eye
MeSH Terms
  • Animals
  • Body Patterning
  • Eye/embryology
  • Eye/metabolism
  • Gene Expression Regulation, Developmental/physiology*
  • Humans
  • Morphogenesis/physiology*
  • Neural Plate/embryology*
  • Neural Plate/metabolism
  • Wnt Signaling Pathway/physiology*
PubMed
24115566 Full text @ Dev. Neurobiol.
Abstract

Wnts are essential for a multitude of processes during embryonic development and adult homeostasis. The molecular structure of the Wnt pathway is extremely complex, and it keeps growing as new molecular components and novel interactions are uncovered. Recent studies have advanced our understanding on how the diverse molecular outcomes of the Wnt pathway are integrated during organ development, an integration that is also essential, although mechanistically poorly understood, during the formation of the anterior part of the nervous system, the forebrain. In this article, the author has summarized these findings and discussed their implications for forebrain development. A special emphasis has been put forth on studies performed in the zebrafish as this model system has been instrumental for our current understanding of forebrain patterning.

Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Errata and Notes