ZFIN ID: ZDB-PUB-131029-22
Recent advances in heart regeneration
Xiong, J.W., and Chang N.N.
Date: 2013
Source: Birth defects research. Part C, Embryo today : reviews   99(3): 160-169 (Review)
Registered Authors: Xiong, Jing-Wei
Keywords: cardiac progenitors, cardiac tissue engineering, heart regeneration, zebrafish, mouse
MeSH Terms:
  • Animals
  • Cell Proliferation
  • Disease Models, Animal
  • Humans
  • Mice
  • Myocardium/cytology*
  • Myocardium/metabolism*
  • Myocytes, Cardiac/transplantation
  • Regeneration*
  • Regenerative Medicine/methods*
  • Stem Cell Transplantation
  • Stem Cells
  • Tissue Engineering/methods
  • Zebrafish
PubMed: 24078494 Full text @ Birth Defects Res. C Embryo Today
Although cardiac stem cells (CSCs) and tissue engineering are very promising for cardiac regenerative medicine, studies with model organisms for heart regeneration will provide alternative therapeutic targets and opportunities. Here, we present a review on heart regeneration, with a particular focus on the most recent work in mouse and zebrafish. We attempt to summarize the recent progresses and bottlenecks of CSCs and tissue engineering for heart regeneration; and emphasize what we have learned from mouse and zebrafish regenerative models on discovering crucial genetic and epigenetic factors for stimulating heart regeneration; and speculate the potential application of these regenerative factors for heart failure. A brief perspective highlights several important and promising research directions in this exciting field.