|ZFIN ID: ZDB-PUB-131029-22|
Recent advances in heart regeneration
Xiong, J.W., and Chang N.N.
|Source:||Birth defects research. Part C, Embryo today : reviews 99(3): 160-169 (Review)|
|Registered Authors:||Xiong, Jing-Wei|
|Keywords:||cardiac progenitors, cardiac tissue engineering, heart regeneration, zebrafish, mouse|
|PubMed:||24078494 Full text @ Birth Defects Res. C Embryo Today|
Xiong, J.W., and Chang N.N. (2013) Recent advances in heart regeneration. Birth defects research. Part C, Embryo today : reviews. 99(3):160-169.
ABSTRACTAlthough cardiac stem cells (CSCs) and tissue engineering are very promising for cardiac regenerative medicine, studies with model organisms for heart regeneration will provide alternative therapeutic targets and opportunities. Here, we present a review on heart regeneration, with a particular focus on the most recent work in mouse and zebrafish. We attempt to summarize the recent progresses and bottlenecks of CSCs and tissue engineering for heart regeneration; and emphasize what we have learned from mouse and zebrafish regenerative models on discovering crucial genetic and epigenetic factors for stimulating heart regeneration; and speculate the potential application of these regenerative factors for heart failure. A brief perspective highlights several important and promising research directions in this exciting field.
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