ZFIN ID: ZDB-PUB-130903-51
New and TALENted Genome Engineering Toolbox
Campbell, J.M., Hartjes, K.A., Nelson, T.J., Xu, X., and Ekker, S.C.
Date: 2013
Source: Circulation research 113(5): 571-587 (Review)
Registered Authors: Ekker, Stephen C., Xu, Xiaolei
Keywords: cardiovascular disease modeling, genome engineering, induced pluripotent stem cells, TALENs, zebrafish
MeSH Terms: Animals; Bacterial Proteins/genetics; Bacterial Proteins/physiology*; Binding Sites; Cardiovascular Diseases/genetics* (all 34) expand
PubMed: 23948583 Full text @ Circ. Res.
ABSTRACT

Recent advances in the burgeoning field of genome engineering are accelerating the realization of personalized therapeutics for cardiovascular disease. In the postgenomic era, sequence-specific gene-editing tools enable the functional analysis of genetic alterations implicated in disease. In partnership with high-throughput model systems, efficient gene manipulation provides an increasingly powerful toolkit to study phenotypes associated with patient-specific genetic defects. Herein, this review emphasizes the latest developments in genome engineering and how applications within the field are transforming our understanding of personalized medicine with an emphasis on cardiovascular diseases.

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