Campbell, J.M., Hartjes, K.A., Nelson, T.J., Xu, X., and Ekker, S.C. (2013) New and TALENted Genome Engineering Toolbox. Circulation research. 113(5):571-587.
Recent advances in the burgeoning field of genome engineering are accelerating the realization of personalized therapeutics
for cardiovascular disease. In the postgenomic era, sequence-specific gene-editing tools enable the functional analysis of
genetic alterations implicated in disease. In partnership with high-throughput model systems, efficient gene manipulation
provides an increasingly powerful toolkit to study phenotypes associated with patient-specific genetic defects. Herein, this
review emphasizes the latest developments in genome engineering and how applications within the field are transforming our
understanding of personalized medicine with an emphasis on cardiovascular diseases.