ZFIN ID: ZDB-PUB-130722-9
TB: the Yin and Yang of lipid mediators
Tobin, D.M., and Ramakrishnan, L.
Date: 2013
Source: Current opinion in pharmacology   13(4): 641-5 (Review)
Registered Authors: Ramakrishnan, Lalita, Tobin, David
Keywords: none
MeSH Terms:
  • Animals
  • Epoxide Hydrolases/immunology*
  • Humans
  • Inflammation Mediators/immunology*
  • Lipoxins/immunology*
  • Tuberculosis/immunology*
PubMed: 23849093 Full text @ Curr. Opin. Pharmacol.

There is a growing appreciation of the diverse roles that lipid mediators play in modulating inflammatory responses during infection. In the case of tuberculosis, virulent mycobacteria induce host production of anti-inflammatory mediators, including lipoxins, which limit the host inflammatory response and lead to necrotic cell death of infected macrophages. Recent work using the zebrafish model suggests that, while excess anti-inflammatory lipoxins are host detrimental during mycobacterial infections, excess pro-inflammatory lipids also drive host susceptibility. The balance of these inflammatory states is influenced by common human genetic variation in Asia. Fuller understanding of the mechanisms of eicosanoid-mediated inflammatory imbalance during tuberculosis infection has important implications for the development of adjunctive therapies.