G protein-coupled receptors in vascular development
- Authors
- Li, F.F., Li, W.Q., and Jing, Q.
- ID
- ZDB-PUB-130610-25
- Date
- 2013
- Source
- Yi chuan = Hereditas 35(4): 459-467 (Journal)
- Registered Authors
- Li, Fangfang
- Keywords
- none
- MeSH Terms
-
- Animals
- Blood Vessels/cytology
- Blood Vessels/growth & development
- Blood Vessels/metabolism*
- Blood Vessels/physiology
- Endothelial Cells/cytology
- Endothelial Cells/metabolism
- Humans
- Neovascularization, Physiologic
- Receptors, G-Protein-Coupled/metabolism*
- PubMed
- 23659936 Full text @ Yi Chuan
The vascular development consists of two continuous processes: vasculogenesis and angiogenesis. Some researches showed that G protein-coupled receptors (GPCRs) play important roles in these processes, including the regulation of differentiation, migration and coalescence of angioblasts, fate decision of tip and stalk cells, proliferation and migration of endothelial cells and tube formation. For the key events of vasculogenesis and angiogenesis, we summarize the recent advance of GPCRs, especially Class A and F. In particular, the advantages, of zebrafish, which has been widely used in developmental biology as a vertebrate model, are introduced. Using zebrafish will bring the great potential and prospect to demonstrate the role of GPCRs in vascular development in the future.