ZFIN ID: ZDB-PUB-130418-9
Getting out and about: the emergence and morphogenesis of the vertebrate lymphatic vasculature
Koltowska, K., Betterman, K.L., Harvey, N.L., and Hogan, B.M.
Date: 2013
Source: Development (Cambridge, England)   140(9): 1857-1870 (Review)
Registered Authors: Hogan, Ben M.
Keywords: lymphatic vasculature, morphogenesis, vertebrate embryo
MeSH Terms:
  • Animals
  • Biological Evolution
  • Cell Movement
  • Endothelium, Vascular/cytology
  • Endothelium, Vascular/metabolism
  • Ephrin-B2/genetics
  • Ephrin-B2/metabolism
  • Forkhead Transcription Factors/genetics
  • Forkhead Transcription Factors/metabolism
  • Homeodomain Proteins/genetics
  • Homeodomain Proteins/metabolism
  • Lymphangiogenesis*
  • Lymphatic Vessels/cytology
  • Lymphatic Vessels/embryology*
  • Mice
  • Morphogenesis*
  • Receptors, Vascular Endothelial Growth Factor/genetics
  • Receptors, Vascular Endothelial Growth Factor/metabolism
  • Signal Transduction
  • Tumor Suppressor Proteins/genetics
  • Tumor Suppressor Proteins/metabolism
  • Zebrafish/embryology
  • Zebrafish/genetics
  • Zebrafish/metabolism
PubMed: 23571211 Full text @ Development

The lymphatic vascular system develops from the pre-existing blood vasculature of the vertebrate embryo. New insights into lymphatic vascular development have recently been achieved with the use of alternative model systems, new molecular tools, novel imaging technologies and growing interest in the role of lymphatic vessels in human disorders. The signals and cellular mechanisms that facilitate the emergence of lymphatic endothelial cells from veins, guide migration through the embryonic environment, mediate interactions with neighbouring tissues and control vessel maturation are beginning to emerge. Here, we review the most recent advances in lymphatic vascular development, with a major focus on mouse and zebrafish model systems.