PUBLICATION
A click-activated fluorescent probe for selective detection of hydrazoic acid and its application in biological imaging
- Authors
- Zhou, Y., Yao, Y.W., Qi, Q., Fang, Y., Li, J.Y., and Yao, C.
- ID
- ZDB-PUB-130410-1
- Date
- 2013
- Source
- Chemical communications (Cambridge, England) 49(53): 5924-6 (Journal)
- Registered Authors
- Zhou, Yi
- Keywords
- none
- MeSH Terms
-
- Alkynes/chemistry*
- Animals
- Azides/analysis*
- Azides/chemistry
- Click Chemistry
- Diagnostic Imaging
- Fluorescent Dyes/chemistry*
- HeLa Cells
- Humans
- Zebrafish
- PubMed
- 23525157 Full text @ Chem. Commun. (Camb.)
Citation
Zhou, Y., Yao, Y.W., Qi, Q., Fang, Y., Li, J.Y., and Yao, C. (2013) A click-activated fluorescent probe for selective detection of hydrazoic acid and its application in biological imaging. Chemical communications (Cambridge, England). 49(53):5924-6.
Abstract
Here we present a new approach to aqueous hydrazoic acid detection through the synthesis and evaluation of an alkyne-based fluorescent probe, which could be applied in the monitoring of hydrazoic acid in both living Hela cells and larval zebrafish. This probe can also serve as an early warning automaton which would alert when both azide and protons exist over the threshold value.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping