PUBLICATION

Suppression of Pu.1 Function results in expanded myelopoiesis in zebrafish

Authors
Sun, J., Liu, W., Li, L., Chen, J., Wu, M., Zhang, Y., Leung, A.Y., Zhang, W., Wen, Z., and Liao, W.
ID
ZDB-PUB-130322-2
Date
2013
Source
Leukemia   27(9): 1913-7 (Other)
Registered Authors
Li, Li, Zhang, Yiyue
Keywords
none
MeSH Terms
  • Animals
  • Cell Line
  • Gene Expression Regulation
  • Mutation
  • Myelopoiesis/genetics*
  • Proto-Oncogene Proteins/genetics*
  • Proto-Oncogene Proteins/metabolism
  • Trans-Activators/genetics*
  • Trans-Activators/metabolism
  • Zebrafish/genetics*
  • Zebrafish/metabolism
PubMed
23455395 Full text @ Leukemia
Abstract

PU.1 is a member of Ets-family transcription factors, which is indispensable for generating early myeloid progenitors and for the determination of monocytic versus granulocytic lineages during myelopoiesis. Apart from its early function in myelopoiesis, PU.1 is also reported to be involved in leukemogenesis in mice and human. It has been shown that PU.1 expression is downregulated in human acute myeloid leukemia (AML) patients, and PU.1 mutations are found in about 7% of the patients in a study involving 126 AML patients. Likewise, reduction of PU.1 activity leads to AML in mice.

Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping