ZFIN ID: ZDB-PUB-130129-4
Acid-sensing ion channels (ASICs) in the taste buds of adult zebrafish
Viña, E., Parisi, V., Cabo, R., Laurà, R., López-Velasco, S., López-Muñiz, A., García-Suárez, O., Germanà, A., and Vega, J.A.
Date: 2013
Source: Neuroscience letters   536: 35-40 (Journal)
Registered Authors: Germanà, Antonino
Keywords: acid-sensing ion channels, taste buds, zebrafish
MeSH Terms:
  • Acid Sensing Ion Channels/metabolism*
  • Animals
  • Mouth/cytology
  • Mouth/innervation
  • Mouth/metabolism
  • Skin/cytology
  • Skin/innervation
  • Skin/metabolism
  • Taste Buds/metabolism*
  • Zebrafish/metabolism*
PubMed: 23328442 Full text @ Neurosci. Lett.

In detecting chemical properties of food, different molecules and ion channels are involved including members of the acid-sensing ion channels (ASICs) family. Consistently ASICs are present in sensory cells of taste buds of mammals. In the present study the presence of ASICs (ASIC1, ASIC2, ASIC3 and ASIC4) was investigated in the taste buds of adult zebrafish (zASICs) using Western blot and immunohistochemistry. zASIC1 and zASIC3 were regularly absent from taste buds, whereas faint zASIC2 and robust zASIC4 immunoreactivities were detected in sensory cells. Moreover, zASIC2 also immunolabelled nerves supplying taste buds. The present results demonstrate for the first time the presence of zASICs in taste buds of teleosts, with different patterns to that occurring in mammals, probably due to the function of taste buds in aquatic environment and feeding. Nevertheless, the role of zASICs in taste remains to be demonstrated.