PUBLICATION
Jatropholane-Type Diterpenes from Euphorbia sikkimensis
- Authors
- Yang, D.S., Zhang, Y.L., Peng, W.B., Wang, L.Y., Li, Z.L., Wang, X., Liu, K.C., Yang, Y.P., Li, H.L., and Li, X.L.
- ID
- ZDB-PUB-130125-18
- Date
- 2013
- Source
- Journal of natural products 76(2): 265-269 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Algorithms
- Angiogenesis Inhibitors/chemistry
- Angiogenesis Inhibitors/isolation & purification*
- Angiogenesis Inhibitors/pharmacology
- Animals
- Disease Models, Animal
- Diterpenes/chemistry
- Diterpenes/isolation & purification*
- Diterpenes/pharmacology
- Drug Screening Assays, Antitumor
- Drugs, Chinese Herbal/chemistry
- Drugs, Chinese Herbal/isolation & purification*
- Drugs, Chinese Herbal/pharmacology
- Euphorbia/chemistry*
- Humans
- Molecular Structure
- Nuclear Magnetic Resonance, Biomolecular
- Zebrafish
- PubMed
- 23327832 Full text @ J. Nat. Prod.
Citation
Yang, D.S., Zhang, Y.L., Peng, W.B., Wang, L.Y., Li, Z.L., Wang, X., Liu, K.C., Yang, Y.P., Li, H.L., and Li, X.L. (2013) Jatropholane-Type Diterpenes from Euphorbia sikkimensis. Journal of natural products. 76(2):265-269.
Abstract
Four new jatropholane-type diterpenes (1–4), named sikkimenoids A–D, were isolated from the aerial parts of Euphorbia sikkimensis. The structural elucidations of 1–4 were accomplished by extensive NMR analyses, and their absolute configurations were established by ECD calculations. Compound 2 exhibited weak antiangiogenic activity with an IC50 value of 43.0 μM when evaluated using a zebrafish model.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping