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ZIRC
ZFIN ID: ZDB-PUB-121205-8
Zebrafish genetics gets the Scube on Hedgehog secretion
Ingham, P.W.
Date: 2012
Source: Genes & Development   26(22): 2468-2470 (Review)
Registered Authors: Ingham, Philip
Keywords: DispatchedA, Hedgehog, Scube2, morphogen release, palmitate
MeSH Terms: none
PubMed: 23154980 Full text @ Genes & Dev.
ABSTRACT

Inspired by a zebrafish mutation, two recent studies by Creanga and colleagues (pp. 1312–1325) and Tukachinsky and colleagues have shed new light on the way in which lipidated Hedgehog proteins are secreted and released from expressing cells, suggesting a model for the sequential action of the Disp and Scube2 proteins in this process.

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