Overlapping cardiac programs in heart development and regeneration
- Authors
- Zhen, Y.S., Wu, Q., Xiao, C.L., Chang, N.N., Wang, X., Lei, L., Zhu, X., and Xiong, J.W.
- ID
- ZDB-PUB-121010-23
- Date
- 2012
- Source
- Journal of genetics and genomics = Yi chuan xue bao 39(9): 443-449 (Review)
- Registered Authors
- Xiong, Jing-Wei
- Keywords
- cardiac progenitors, heart development, heart regeneration, zebrafish
- MeSH Terms
-
- Animals
- Embryo, Nonmammalian
- Embryonic Development*
- Heart/growth & development*
- Humans
- Regeneration/physiology*
- Regenerative Medicine
- Signal Transduction
- Zebrafish*/embryology
- Zebrafish*/growth & development
- PubMed
- 23021544 Full text @ J. Genet. Genomics
Gaining cellular and molecular insights into heart development and regeneration will likely provide new therapeutic targets and opportunities for cardiac regenerative medicine, one of the most urgent clinical needs for heart failure. Here we present a review on zebrafish heart development and regeneration, with a particular focus on early cardiac progenitor development and their contribution to building embryonic heart, as well as cellular and molecular programs in adult zebrafish heart regeneration. We attempt to emphasize that the signaling pathways shaping cardiac progenitors in heart development may also be redeployed during the progress of adult heart regeneration. A brief perspective highlights several important and promising research areas in this exciting field.