Matsui, T., and Bessho, Y. (2012) Left-right asymmetry in zebrafish. Cellular and molecular life sciences : CMLS. 69(18):3069-3077.
In vertebrates, internal organs are positioned asymmetrically across the left–right (LR) axis, placing them in a defined area
within the body. This LR asymmetric placement is a conserved feature of the vertebrate body plan. Events determining LR asymmetry
occur during embryonic development, and are regulated by the coordinated action of genetic mechanisms that are evolutionarily
conserved among vertebrates. Recent studies using zebrafish have provided new insights into how the Kupffer’s vesicle organizer
region is generated, and how it relays LR asymmetry information to the lateral plate mesoderm. In this review, we summarize
recent advances in zebrafish and describe our current understanding of the mechanisms underlying these processes.
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