PUBLICATION
Cardiac regeneration
- Authors
- Choi, W.Y., and Poss, K.D.
- ID
- ZDB-PUB-120329-5
- Date
- 2012
- Source
- Current topics in developmental biology 100: 319-344 (Chapter)
- Registered Authors
- Choi, Wen-Yee, Poss, Kenneth D.
- Keywords
- heart regeneration, heart development, regeneration, cardiomyocyte, stem cell, epicardium, endocardium
- MeSH Terms
-
- Animals
- Cell- and Tissue-Based Therapy
- Disease Models, Animal
- Heart/physiology*
- Heart Injuries/metabolism
- Heart Injuries/therapy
- Humans
- Regeneration*
- PubMed
- 22449849 Full text @ Curr. Top. Dev. Biol.
Citation
Choi, W.Y., and Poss, K.D. (2012) Cardiac regeneration. Current topics in developmental biology. 100:319-344.
Abstract
The heart is a pump that is comprised of cardiac myocytes and other cell types and whose proper function is critical to quality of life. The ability to trigger regeneration of heart muscle following injury eludes adult mammals, a deficiency of great clinical impact. Major research efforts are attempting to change this through advances in cell therapy or activating endogenous regenerative mechanisms that exist only early in life. In contrast with mammals, lower vertebrates like zebrafish demonstrate an impressive natural capacity for cardiac regeneration throughout life. This review will cover recent progress in the field of heart regeneration with a focus on endogenous regenerative capacity and its potential manipulation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping