Dehnert, K.W., Baskin, J.M., Laughlin, S.T., Beahm, B.J., Naidu, N.N., Amacher, S.L., and Bertozzi, C.R. (2012) Imaging the Sialome during Zebrafish Development with Copper-Free Click Chemistry. Chembiochem : a European journal of chemical biology. 13(3):353-357.
The sialome is comprised of sialylated glycoproteins and glycolipids that play essential roles in cell–cell communication. Using azide-modified molecular precursors of sialic acids and copper-free click chemistry, we visualized the spatiotemporal dynamics of the sialome in live zebrafish embryos.
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