|ZFIN ID: ZDB-PUB-111117-24|
|Source:||The Journal of biological chemistry 286(52): 45116-30 (Journal)|
|Registered Authors:||Cui, Zongbin, Li, Qing, Long, Yong|
|Keywords:||beta-catenin, bone morphogenetic protein (BMP), STAT3, Wnt signaling, zebrafish, convergence and extension, dorsoventral patterning, Lzts2|
Active Transport, Cell Nucleus/physiology; Animals; Body Patterning/physiology*; Cell Movement/physiology; Cell Nucleus/genetics
|PubMed:||22057270 Full text @ J. Biol. Chem.|
Background: The activities of Leucine zipper tumor suppressor 2 (Lzts2) in vertebrate embryogenesis remain unclear.
Results: Lzts2 regulates gastrula C&E movements, dorsoventral patterning, and midline convergence and specification of organ precursors in zebrafish.
Conclusion: Lzts2 functions through interaction with and the export of nuclear β-catenins.
Significance: This work has uncovered the developmental roles of Lzts2 and regulatory mechanisms in zebrafish.