ZFIN ID: ZDB-PUB-111117-24
Lzts2 Regulates Embryonic Cell Movements and Dorsoventral Patterning through Interaction with and Export of Nuclear β-Catenin in Zebrafish
Li, Y., Li, Q., Long, Y., and Cui, Z.
Date: 2011
Source: The Journal of biological chemistry 286(52): 45116-30 (Journal)
Registered Authors: Cui, Zongbin, Li, Qing, Long, Yong
Keywords: beta-catenin, bone morphogenetic protein (BMP), STAT3, Wnt signaling, zebrafish, convergence and extension, dorsoventral patterning, Lzts2
MeSH Terms: Active Transport, Cell Nucleus/physiology; Animals; Body Patterning/physiology*; Cell Movement/physiology; Cell Nucleus/genetics (all 24) expand
PubMed: 22057270 Full text @ J. Biol. Chem.
FIGURES   (current status)

Background: The activities of Leucine zipper tumor suppressor 2 (Lzts2) in vertebrate embryogenesis remain unclear.

Results: Lzts2 regulates gastrula C&E movements, dorsoventral patterning, and midline convergence and specification of organ precursors in zebrafish.

Conclusion: Lzts2 functions through interaction with and the export of nuclear β-catenins.

Significance: This work has uncovered the developmental roles of Lzts2 and regulatory mechanisms in zebrafish.