PUBLICATION

Molecular-genetic mapping of zebrafish mutants with variable phenotypic penetrance

Authors
Jain, R.A., Wolman, M.A., Schmidt, L.A., Burgess, H.A., and Granato, M.
ID
ZDB-PUB-111114-20
Date
2011
Source
PLoS One   6(10): e26510 (Journal)
Registered Authors
Burgess, Harold, Granato, Michael, Jain, Roshan, Wolman, Marc
Keywords
none
MeSH Terms
  • Animals
  • Mutation*
  • Phenotype
  • Zebrafish/genetics*
PubMed
22039502 Full text @ PLoS One
Abstract

Forward genetic screens in vertebrates are powerful tools to generate models relevant to human diseases, including neuropsychiatric disorders. Variability in phenotypic penetrance and expressivity is common in these disorders and behavioral mutant models, making their molecular-genetic mapping a formidable task. Using a ‘phenotyping by segregation’ strategy, we molecularly map the hypersensitive zebrafish houdini mutant despite its variable phenotypic penetrance, providing a generally applicable strategy to map zebrafish mutants with subtle phenotypes.

Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping