PUBLICATION
Molecular evolution of hemojuvelin and the repulsive guidance molecule family
- Authors
- Camus, L.M., and Lambert, L.A.
- ID
- ZDB-PUB-111109-1
- Date
- 2007
- Source
- Journal of molecular evolution 65(1): 68-81 (Journal)
- Registered Authors
- Keywords
- hemojuvelin, repulsive guidance molecule, bone morphogenetic protein, hemochromatosis, iron homeostasis, RGD motif, cell signaling
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Cattle
- Evolution, Molecular*
- Fishes
- GPI-Linked Proteins
- Humans
- Membrane Proteins/genetics*
- Mice
- Molecular Sequence Data
- Multigene Family
- Nerve Tissue Proteins/genetics*
- Phylogeny
- Rats
- Sequence Alignment
- PubMed
- 17593421 Full text @ J. Mol. Evol.
Citation
Camus, L.M., and Lambert, L.A. (2007) Molecular evolution of hemojuvelin and the repulsive guidance molecule family. Journal of molecular evolution. 65(1):68-81.
Abstract
Repulsive guidance molecules (RGMs) are found in vertebrates and chordates and are involved in embryonic development and iron homeostasis. Members of this family are GPI-linked membrane proteins that contain an N-terminal signal peptide, a C-terminal propeptide, and a conserved RGD motif. Vertebrates are known to possess three paralogues; RGMA and RGMB (sometimes called Dragon) are expressed in the nervous system and are thought to play various roles in neural development. Hemojuvelin (HJV; also called repulsive guidance molecule c, RGMC) is the third member of this family, and mutations in this gene result in a form of juvenile hemochromatosis (type 2A). Phylogenetic analyses of 55 different RGM family sequences from 21 different species support the existence of a novel gene, found only in fish, which we have labeled RGMD. The pattern of conserved residues in each family identifies new candidates for important functional roles, including ligand binding.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping