ZFIN ID: ZDB-PUB-111011-25
Patterning and Development of the Atrioventricular Canal in Zebrafish
Peal, D.S., Lynch, S.N., and Milan, D.J.
Date: 2011
Source: Journal of cardiovascular translational research   4(6): 720-6 (Journal)
Registered Authors: Milan, David J.
Keywords: atrioventricular canal, zebrafish
MeSH Terms:
  • Animals
  • Body Patterning
  • Endocardial Cushions/embryology*
  • Endocardial Cushions/metabolism
  • Gene Expression Regulation, Developmental
  • Heart Valves/embryology*
  • Heart Valves/metabolism
  • Morphogenesis*
  • Signal Transduction
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish/metabolism
PubMed: 21948390 Full text @ J.Cardiovasc. Transl. Res.
Proper atrioventricular canal (AVC) patterning and subsequent valvulogenesis is a complex process, and defects can result in disease or early death. The zebrafish Danio rerio has become a useful model system for studying AVC development, and much progress has been made in dissecting out the critical steps. Here, we review the recent advances in the field and highlight the cellular and molecular changes observed during zebrafish AVC development.