Cavodeassi, F., and Houart, C. (2012) Brain regionalisation: Of signalling centres and boundaries. Developmental Neurobiology. 72(3):218-233.
Our knowledge of the general mechanisms controlling the formation of the vertebrate central nervous system has advanced tremendously in the last decade. Here, we discuss the impact of the combined use of cell manipulation, in vivo imaging and genetics in the zebrafish on recent progress in understanding how signalling processes progressively control regionalisation of the central nervous system. We highlight the unresolved issues and speculate upon the fundamental role the zebrafish will continue having in answering them.