ZFIN ID: ZDB-PUB-110629-21
Brain regionalisation: Of signalling centres and boundaries
Cavodeassi, F., and Houart, C.
Date: 2012
Source: Developmental Neurobiology   72(3): 218-233 (Review)
Registered Authors: Cavodeassi, Florencia, Houart, Corinne
Keywords: brain, CNS, neural plate, local organisers, signalling centres, morphogens, pattern formation, fate specification
MeSH Terms:
  • Animals
  • Brain/embryology
  • Brain/growth & development*
  • Cell Communication/physiology*
  • Humans
  • Morphogenesis/physiology
  • Signal Transduction/physiology*
  • Transcription, Genetic/physiology
  • Zebrafish
PubMed: 21692189 Full text @ Dev. Neurobiol.
Our knowledge of the general mechanisms controlling the formation of the vertebrate central nervous system has advanced tremendously in the last decade. Here, we discuss the impact of the combined use of cell manipulation, in vivo imaging and genetics in the zebrafish on recent progress in understanding how signalling processes progressively control regionalisation of the central nervous system. We highlight the unresolved issues and speculate upon the fundamental role the zebrafish will continue having in answering them.