ZFIN ID: ZDB-PUB-110613-22
Evolutionary plasticity of segmentation clock networks
Krol, A.J., Roellig, D., Dequéant, M.L., Tassy, O., Glynn, E., Hattem, G., Mushegian, A., Oates, A.C., and Pourquié, O.
Date: 2011
Source: Development (Cambridge, England)   138(13): 2783-2792 (Journal)
Registered Authors: Oates, Andrew, Roellig, Daniela
Keywords: somitogenesis, segmentation, evolution, cyclic genes, segmentation clock, microarray, chicken, zebrafish, mouse, notch, wnt, FGF
MeSH Terms:
  • Animals
  • Biological Clocks/genetics
  • Biological Clocks/physiology*
  • Chickens
  • Evolution, Molecular*
  • Fibroblast Growth Factors/genetics
  • Fibroblast Growth Factors/metabolism
  • In Situ Hybridization
  • Mice
  • Oligonucleotide Array Sequence Analysis
  • Polymerase Chain Reaction
  • Receptors, Notch/genetics
  • Receptors, Notch/metabolism
  • Signal Transduction/genetics
  • Signal Transduction/physiology
  • Wnt Proteins/genetics
  • Wnt Proteins/metabolism
  • Zebrafish
PubMed: 21652651 Full text @ Development
The vertebral column is a conserved anatomical structure that defines the vertebrate phylum. The periodic or segmental pattern of the vertebral column is established early in development when the vertebral precursors, the somites, are rhythmically produced from presomitic mesoderm (PSM). This rhythmic activity is controlled by a segmentation clock that is associated with the periodic transcription of cyclic genes in the PSM. Comparison of the mouse, chicken and zebrafish PSM oscillatory transcriptomes revealed networks of 40 to 100 cyclic genes mostly involved in Notch, Wnt and FGF signaling pathways. However, despite this conserved signaling oscillation, the identity of individual cyclic genes mostly differed between the three species, indicating a surprising evolutionary plasticity of the segmentation networks.