ZFIN ID: ZDB-PUB-110524-24
Dopaminergic and noradrenergic circuit development in zebrafish
Schweitzer, J., Löhr, H., Filippi, A., and Driever, W.
Date: 2012
Source: Developmental Neurobiology   72(3): 256-268 (Review)
Registered Authors: Driever, Wolfgang, Filippi, Alida, Löhr, Heiko, Schweitzer, Jörn
Keywords: none
MeSH Terms:
  • Adrenergic Neurons/cytology
  • Adrenergic Neurons/physiology*
  • Animals
  • Dopaminergic Neurons/physiology*
  • Humans
  • Nerve Net/cytology
  • Nerve Net/growth & development*
  • Nerve Net/metabolism
  • Neurogenesis/physiology
  • Zebrafish/growth & development*
  • Zebrafish/metabolism
  • Zebrafish Proteins/biosynthesis
PubMed: 21567980 Full text @ Dev. Neurobiol.
Dopaminergic and noradrenergic neurons constitute some of major far projecting systems in the vertebrate brain and spinal cord that modulate the activity of circuits controlling a broad range of behaviors. Degeneration or dysfunction of dopaminergic neurons has also been linked to a number of neurological and psychiatric disorders, including Parkinson's disease. Zebrafish (Danio rerio) have emerged over the past two decades into a major genetic vertebrate model system, and thus contributed to a better understanding of developmental mechanisms controlling dopaminergic neuron specification and axonogenesis. In this review, we want to focus on conserved and dynamic aspects of the different catecholaminergic systems, which may help to evaluate the zebrafish as a model for dopaminergic and noradrenergic cellular specification and circuit function as well as biomedical aspects of catecholamine systems.