Synthesis of a new fluorescent small molecule probe and its use for in vivo lipid imaging
- Lee, J.H., So, J.H., Jeon, J.H., Choi, E.B., Lee, Y.R., Chang, Y.T., Kim, C.H., Bae, M.A., and Ahn, J.H.
- Chemical communications (Cambridge, England) 47(26): 7500-2 (Journal)
- Registered Authors
- Kim, Cheol-Hee, So, Ju-Hoon
- MeSH Terms
- 3T3-L1 Cells
- Adipose Tissue/metabolism
- Fluorescent Dyes/chemical synthesis*
- Fluorescent Dyes/chemistry*
- Lipid Metabolism*
- Molecular Imaging/methods*
- 21552617 Full text @ Chem. Commun. (Camb.)
Lee, J.H., So, J.H., Jeon, J.H., Choi, E.B., Lee, Y.R., Chang, Y.T., Kim, C.H., Bae, M.A., and Ahn, J.H. (2011) Synthesis of a new fluorescent small molecule probe and its use for in vivo lipid imaging. Chemical communications (Cambridge, England). 47(26):7500-2.
A new small molecule probe for in vivo lipid imaging, LipidGreen (compound 5), was developed. LipidGreen stained lipid droplets in 3T3L1 cell lines and fat deposits in zebrafish without apparent toxicity up to 100 μM. The utility of LipidGreen as a drug screening platform for fat regulation was also demonstrated in live zebrafish.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes