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ZFIN ID: ZDB-PUB-110523-13
Synthesis of a new fluorescent small molecule probe and its use for in vivo lipid imaging
Lee, J.H., So, J.H., Jeon, J.H., Choi, E.B., Lee, Y.R., Chang, Y.T., Kim, C.H., Bae, M.A., and Ahn, J.H.
Date: 2011
Source: Chemical communications (Cambridge, England)   47(26): 7500-2 (Journal)
Registered Authors: Kim, Cheol-Hee, So, Ju-Hoon
Keywords: none
MeSH Terms:
  • 3T3-L1 Cells
  • Adipose Tissue/metabolism
  • Animals
  • Fluorescent Dyes/chemical synthesis*
  • Fluorescent Dyes/chemistry*
  • Lipid Metabolism*
  • Mice
  • Molecular Imaging/methods*
  • Zebrafish
PubMed: 21552617 Full text @ Chem. Commun. (Camb.)
A new small molecule probe for in vivo lipid imaging, LipidGreen (compound 5), was developed. LipidGreen stained lipid droplets in 3T3L1 cell lines and fat deposits in zebrafish without apparent toxicity up to 100 μM. The utility of LipidGreen as a drug screening platform for fat regulation was also demonstrated in live zebrafish.