ZFIN ID: ZDB-PUB-110512-17
Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish
Hicken, C.E., Linbo, T.L., Baldwin, D.H., Willis, M.L., Myers, M.S., Holland, L., Larsen, M., Stekoll, M.S., Rice, S.D., Collier, T.K., Scholz, N.L., and Incardona, J.P.
Date: 2011
Source: Proceedings of the National Academy of Sciences of the United States of America   108(17): 7086-7090 (Journal)
Registered Authors: Baldwin, David, Incardona, John P., Linbo, Tiffany L.
Keywords: cardiac toxicity, fish populations, heart development, oil spills
MeSH Terms:
  • Animals
  • Cytochrome P-450 Enzyme System/biosynthesis*
  • Ecosystem*
  • Female
  • Fish Diseases*/chemically induced
  • Fish Diseases*/enzymology
  • Fish Diseases*/pathology
  • Heart Failure*/chemically induced
  • Heart Failure*/enzymology
  • Heart Failure*/pathology
  • Heart Failure*/veterinary
  • Male
  • Myocardium*/enzymology
  • Myocardium*/pathology
  • Petroleum/toxicity*
  • Polycyclic Aromatic Hydrocarbons/toxicity*
  • Water Pollutants, Chemical/toxicity*
  • Zebrafish/metabolism*
  • Zebrafish Proteins/biosynthesis
PubMed: 21482755 Full text @ Proc. Natl. Acad. Sci. USA
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ABSTRACT
Exposure to high concentrations of crude oil produces a lethal syndrome of heart failure in fish embryos. Mortality is caused by cardiotoxic polycyclic aromatic hydrocarbons (PAHs), ubiquitous components of petroleum. Here, we show that transient embryonic exposure to very low concentrations of oil causes toxicity that is sublethal, delayed, and not counteracted by the protective effects of cytochrome P450 induction. Nearly a year after embryonic oil exposure, adult zebrafish showed subtle changes in heart shape and a significant reduction in swimming performance, indicative of reduced cardiac output. These delayed physiological impacts on cardiovascular performance at later life stages provide a potential mechanism linking reduced individual survival to population-level ecosystem responses of fish species to chronic, low-level oil pollution.
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