PUBLICATION
Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish
- Authors
- Hicken, C.E., Linbo, T.L., Baldwin, D.H., Willis, M.L., Myers, M.S., Holland, L., Larsen, M., Stekoll, M.S., Rice, S.D., Collier, T.K., Scholz, N.L., and Incardona, J.P.
- ID
- ZDB-PUB-110512-17
- Date
- 2011
- Source
- Proceedings of the National Academy of Sciences of the United States of America 108(17): 7086-7090 (Journal)
- Registered Authors
- Baldwin, David, Incardona, John P., Linbo, Tiffany L.
- Keywords
- cardiac toxicity, fish populations, heart development, oil spills
- MeSH Terms
-
- Animals
- Cytochrome P-450 Enzyme System/biosynthesis*
- Ecosystem*
- Female
- Fish Diseases*/chemically induced
- Fish Diseases*/enzymology
- Fish Diseases*/pathology
- Heart Failure*/chemically induced
- Heart Failure*/enzymology
- Heart Failure*/pathology
- Heart Failure*/veterinary
- Male
- Myocardium*/enzymology
- Myocardium*/pathology
- Petroleum/toxicity*
- Polycyclic Aromatic Hydrocarbons/toxicity*
- Water Pollutants, Chemical/toxicity*
- Zebrafish/metabolism*
- Zebrafish Proteins/biosynthesis
- PubMed
- 21482755 Full text @ Proc. Natl. Acad. Sci. USA
Citation
Hicken, C.E., Linbo, T.L., Baldwin, D.H., Willis, M.L., Myers, M.S., Holland, L., Larsen, M., Stekoll, M.S., Rice, S.D., Collier, T.K., Scholz, N.L., and Incardona, J.P. (2011) Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish. Proceedings of the National Academy of Sciences of the United States of America. 108(17):7086-7090.
Abstract
Exposure to high concentrations of crude oil produces a lethal syndrome of heart failure in fish embryos. Mortality is caused by cardiotoxic polycyclic aromatic hydrocarbons (PAHs), ubiquitous components of petroleum. Here, we show that transient embryonic exposure to very low concentrations of oil causes toxicity that is sublethal, delayed, and not counteracted by the protective effects of cytochrome P450 induction. Nearly a year after embryonic oil exposure, adult zebrafish showed subtle changes in heart shape and a significant reduction in swimming performance, indicative of reduced cardiac output. These delayed physiological impacts on cardiovascular performance at later life stages provide a potential mechanism linking reduced individual survival to population-level ecosystem responses of fish species to chronic, low-level oil pollution.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping