PUBLICATION
A review of monoaminergic neuropsychopharmacology in zebrafish
- Authors
- Maximino, C., and Herculano, A.M.
- ID
- ZDB-PUB-101222-30
- Date
- 2010
- Source
- Zebrafish 7(4): 359-378 (Review)
- Registered Authors
- Maximino, Caio
- Keywords
- none
- MeSH Terms
-
- Animals
- Behavior, Animal
- Humans
- Models, Animal
- Neuropharmacology/methods*
- Neurotransmitter Agents/pharmacology*
- Zebrafish*
- PubMed
- 21158565 Full text @ Zebrafish
Citation
Maximino, C., and Herculano, A.M. (2010) A review of monoaminergic neuropsychopharmacology in zebrafish. Zebrafish. 7(4):359-378.
Abstract
Monoamine neurotransmitters are the major regulatory mechanisms in the vertebrate brain, involved in the adjustment of motivation, emotion, and cognition. The chemical anatomy of these systems is thought to be highly conserved in the brain of all vertebrates, including zebrafish. Recently, the development of behavioral assays in zebrafish allowed the neuropsychopharmacological investigation of these circuits and its functions. Here we review neuroanatomical, genetic, neurochemical, and psychopharmacological evidence regarding the roles of histaminergic, dopaminergic, noradrenergic, serotonergic, and melatonergic systems in this species. We conclude that, in spite of species differences, zebrafish are suitable for the investigation of neuropsychopharmacology of drugs that affect theses systems; nonetheless, more thorough validation of behavioral methods is still needed.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping