PUBLICATION
Perspectives on endocrine disruptor effects on metabolic sensors
- Authors
- Migliarini, B., Piccinetti, C.C., Martella, A., Maradonna, F., Gioacchini, G., and Carnevali, O.
- ID
- ZDB-PUB-101209-22
- Date
- 2011
- Source
- General and comparative endocrinology 170(3): 416-423 (Review)
- Registered Authors
- Carnevali, Oliana
- Keywords
- EDs, body weight, food intake, lipid metabolism
- MeSH Terms
-
- Animals
- Body Weight/drug effects
- Diethylhexyl Phthalate/toxicity
- Eating/drug effects
- Endocrine Disruptors/toxicity*
- Hormones/metabolism
- Hypothalamus/drug effects
- Hypothalamus/physiology
- Lipid Metabolism/drug effects
- Metabolic Diseases/etiology
- Metabolic Diseases/metabolism
- Receptors, Cell Surface/drug effects*
- Steroids/metabolism
- Zebrafish
- PubMed
- 21130769 Full text @ Gen. Comp. Endocrinol.
Citation
Migliarini, B., Piccinetti, C.C., Martella, A., Maradonna, F., Gioacchini, G., and Carnevali, O. (2011) Perspectives on endocrine disruptor effects on metabolic sensors. General and comparative endocrinology. 170(3):416-423.
Abstract
Endocrine disrupting chemicals (EDs) can increase or block the metabolism of endogenous peptidergic or steroid hormones by activating or antagonizing nuclear receptors in the hypothalamus, besides adipose tissue, liver and gonads. Toxicological and epidemiological studies have suggested the involvement of different EDs in an increasing number of metabolic disorders such as obesity and diabetes. The aim of this review is to summarize the literature from experimental animal studies demonstrating the impairment of body weight raised by the deregulation of peptidergic signals as well as by the activation of key metabolic molecular targets. Regarding the modification of gene transcription levels induced by EDs, new data on DEHP effect on food intake and lipid metabolism in the experimental model zebrafish (Danio rerio) have also been includedin this review providing evidences about the dangerousness of DEHPlow doses.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping