PUBLICATION
The association between nC(60) and 17{alpha}-ethinylestradiol (EE2) decreases EE2 bioavailability in zebrafish and alters nanoaggregate characteristics
- Authors
- Park, J.W., Henry, T.B., Ard, S., Menn, F.M., Compton, R.N., and Sayler, G.S.
- ID
- ZDB-PUB-101027-32
- Date
- 2011
- Source
- Nanotoxicology 5(3): 406-16 (Journal)
- Registered Authors
- Henry, Theodore B.
- Keywords
- C60 fullerenes, nanoparticles, EE2, co-contaminant, nanoparticle associations
- MeSH Terms
-
- Animals
- Biological Availability
- Ethinyl Estradiol/chemistry
- Ethinyl Estradiol/pharmacokinetics*
- Fullerenes/chemistry*
- Fullerenes/pharmacokinetics*
- Larva/drug effects
- Nanoparticles/chemistry*
- Time Factors
- Zebrafish
- PubMed
- 20969539 Full text @ Nanotoxicology
Citation
Park, J.W., Henry, T.B., Ard, S., Menn, F.M., Compton, R.N., and Sayler, G.S. (2011) The association between nC(60) and 17{alpha}-ethinylestradiol (EE2) decreases EE2 bioavailability in zebrafish and alters nanoaggregate characteristics. Nanotoxicology. 5(3):406-16.
Abstract
Abstract Manufactured nanoparticles (NPs) released into surface waters will associate with other substances and these interactions may affect environmental fate and bioavailability of NPs and the associated substances. We investigated the association between aqueous aggregates of C(60) (nC(60)) and synthetic estrogen, 17α-ethinylestradiol (EE2), and considered nC(60) physicochemistry and EE2 bioavailability (by measuring vitellogenin (vtg1A/B) gene expression) in zebrafish. Bioavailability of EE2 was reduced with increasing concentration of nC(60) (P < 0.05), and bioavailability of EE2 decreased further after aging 28 d with nC(60). Reduction in EE2 bioavailability was correlated with computed surface area of nC(60), and reduced bioavailability of EE2 upon aging was consistent with absorption of EE2 within nC(60) aggregates. Size and zeta potential of nC(60) particles were affected by EE2 (1 μg/L) and also by aging (28 d) in aqueous phase. Results indicate that nC(60) can reduce bioavailability of some substances and influence environmental fate and transport of associated substances.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping