PUBLICATION
Dermoskeleton morphogenesis in zebrafish fins
- Authors
- Marí-Beffa, M., and Murciano, C.
- ID
- ZDB-PUB-101018-6
- Date
- 2010
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 239(11): 2779-2794 (Review)
- Registered Authors
- Marí-Beffa, Manuel
- Keywords
- zebrafish, development, regeneration, fin, fin bud, rays
- MeSH Terms
-
- Animals
- Extremities/anatomy & histology*
- Extremities/embryology*
- Extremities/growth & development
- Models, Biological
- Morphogenesis/physiology
- Zebrafish/anatomy & histology*
- Zebrafish/embryology*
- Zebrafish/growth & development
- Zebrafish/metabolism
- PubMed
- 20931648 Full text @ Dev. Dyn.
Citation
Marí-Beffa, M., and Murciano, C. (2010) Dermoskeleton morphogenesis in zebrafish fins. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(11):2779-2794.
Abstract
Zebrafish fins have a proximal skeleton of endochondral bones and a distal skeleton of dermal bones. Recent experimental and genetic studies are discovering mechanisms to control fin skeleton morphogenesis. Whereas the endochondral skeleton has been extensively studied, the formation of the dermal skeleton requires further revision. The shape of the dermal skeleton of the fin is generated in its distal growing margin and along a proximal growing domain. In these positions, dermoskeletal fin morphogenesis can be explained by intertissue interactions and the function of several genetic pathways. These pathways regulate patterning, size, and cell differentiation along three axes. Finally, a common genetic control of late development, regeneration, and tissue homeostasis of the fin dermoskeleton is currently being analyzed. These pathways may be responsible for the similar shape obtained after each morphogenetic process. This provides an interesting conceptual framework for future studies on this topic.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping