PUBLICATION
Zebrafish as a tool in Alzheimer's disease research
- Authors
- Newman, M., Verdile, G., Martins, R.N., and Lardelli, M.
- ID
- ZDB-PUB-101011-45
- Date
- 2011
- Source
- Biochimica et biophysica acta. Molecular basis of disease 1812(3): 346-352 (Review)
- Registered Authors
- Lardelli, Michael, Newman, Morgan
- Keywords
- Zebrafish, Alzheimer's disease, presenilin
- MeSH Terms
-
- Alzheimer Disease/genetics*
- Alzheimer Disease/pathology
- Animals
- Disease Models, Animal*
- Humans
- Zebrafish/genetics*
- PubMed
- 20920580 Full text @ BBA Molecular Basis of Disease
Citation
Newman, M., Verdile, G., Martins, R.N., and Lardelli, M. (2011) Zebrafish as a tool in Alzheimer's disease research. Biochimica et biophysica acta. Molecular basis of disease. 1812(3):346-352.
Abstract
Alzheimer's disease is the most prevalent form of neurodegenerative disease. Despite many years of intensive research our understanding of the molecular events leading to this pathology is far from complete. No effective treatments have been defined and questions surround the validity and utility of existing animal models. The zebrafish (and, in particular, its embryos) is a malleable and accessible model possessing a vertebrate neural structure and genome. Zebrafish genes ortholgous to those mutated in human familial Alzheimer's disease have been defined. Work in zebrafish has permitted discovery of unique characteristics of these genes that would have been difficult to observe with other models. In this brief review we give an overview of Alzheimer's disease and transgenic animal models before examining the current contribution of zebrafish to this research area.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping