Study on acute toxicity and structure-activity relationship of zebrafish (Danio rerio) exposed to naphthoquinones
- Song, W.H., Ding, F., Guo, J., Li, L.Y., Zhang, J.H., Lian, J., Hu, W.X., and Gao, M.L.
- Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 45(7): 601-605 (Journal)
- Registered Authors
- Hu, Wei, Li, Li
- Zebrafish, naphthoquinones, structure-activity relationship, toxicity
- MeSH Terms
- Models, Animal
- Molecular Structure
- Structure-Activity Relationship
- Water Pollutants, Chemical/chemistry*
- Water Pollutants, Chemical/toxicity*
- 20803362 Full text @ J. Environ. Sci. Health B
Song, W.H., Ding, F., Guo, J., Li, L.Y., Zhang, J.H., Lian, J., Hu, W.X., and Gao, M.L. (2010) Study on acute toxicity and structure-activity relationship of zebrafish (Danio rerio) exposed to naphthoquinones. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 45(7):601-605.
In this paper, we evaluated the acute toxicity of five naphthoquinone compounds, expressed as median lethal concentration at 96 h (LC(50)) using zebrafish as a model. The five compounds were classified as harmful or very toxic. The Gaussian method was used to calculate the quantitative-chemical parameters of each compound. Based on the structure-activity relationship analysis, the interaction between the naphthoquinones and the target is likely mediated by 1-carbonyl and the hydrophobic fraction substituted in alpha -position of naphthoquinone via hydrogen bonding and hydrophobic interactions. Our results provide a foundation for evaluating the aquatic ecological risk and the mode of action of naphthoquinones in the environment.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes