ZFIN ID: ZDB-PUB-100910-11
The HMGB protein gene family in zebrafish: Evolution and embryonic expression patterns
Moleri, S., Cappellano, G., Gaudenzi, G., Cermenati, S., Cotelli, F., Horner, D.S., and Beltrame, M.
Date: 2011
Source: Gene expression patterns : GEP   11(1-2): 3-11 (Journal)
Registered Authors: Beltrame, Monica, Cotelli, Franco
Keywords: High-Mobility group, High-Mobility Group Box, Gene family, Phylogenetic analysis, Molecular evolution, Gene expression, Development, Embryonic development, Vertebrates, Fish, Danio rerio, In situ hybridization, Synteny, Chromatin, Transcription, Recombination, Repair, Inflammation, Innate immunity, Tissue regeneration
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Evolution, Molecular*
  • Gene Expression Regulation, Developmental*
  • HMGB Proteins/chemistry
  • HMGB Proteins/genetics*
  • Humans
  • Molecular Sequence Data
  • Phylogeny
  • Sequence Alignment
  • Zebrafish/embryology*
  • Zebrafish/genetics*
PubMed: 20804857 Full text @ Gene Expr. Patterns
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ABSTRACT
The High-Mobility Group Box (HMGB) proteins are highly abundant proteins with both nuclear and extracellular roles in key biological processes. In mammals, three family members are present: HMGB1, HMGB2 and HMGB3. We characterized the HMGB family in zebrafish and report a detailed phylogenetic analysis of HMGB proteins. The B1, B2, and B3 subfamilies are present in cartilaginous fish, bony fish, and tetrapods, while jawless fish sequences emerge as basal to the gene family expansion. Two co-orthologs of each mammalian HMGB gene are present in zebrafish. All six zebrafish hmgb genes are maternally expressed, but huge differences in expression levels exist during embryonic development. The hmgb2a/hmgb2b genes are the most highly expressed, while hmgb3b is expressed at the lowest level. Remarkably, hmgb3 genes are not present in fugu, medaka, Tetraodon and stickleback. Our analysis highlights substantial overlaps, but also subtle differences and specificities in the expression patterns of the zebrafish hmgb genes.
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