ZFIN ID: ZDB-PUB-100730-16
deLiver'in Regeneration: Injury Response and Development
Curado, S., and Stainier, D.Y.
Date: 2010
Source: Seminars in liver disease   30(3): 288-295 (Review)
Registered Authors: Curado, Silvia, Stainier, Didier
Keywords: Hepatopathology, liver, damage, hepatocyte, biliary cell, oval cell, hepatectomy
MeSH Terms:
  • Animals
  • Cell Proliferation
  • Cell Transdifferentiation
  • Hepatectomy
  • Humans
  • Liver/metabolism
  • Liver/pathology
  • Liver/physiopathology*
  • Liver/surgery
  • Liver Diseases/metabolism
  • Liver Diseases/pathology
  • Liver Diseases/physiopathology*
  • Liver Diseases/therapy
  • Liver Regeneration*
  • Mice
  • Models, Animal
  • Signal Transduction
  • Zebrafish
PubMed: 20665380 Full text @ Semin. Liver Dis.
Liver regeneration has traditionally been investigated in mammalian models. Recent technological developments in mouse genetics have greatly enhanced the resolving power of these studies. In addition, the zebrafish system has emerged as a complementary genetic system to study liver regeneration. One of the most promising attributes of the zebrafish system is its amenability to large-scale screens including genetic and chemical screens. Also, as our understanding of liver development is becoming more detailed, it is important to evaluate the commonalities and differences between organ development and regeneration.