PUBLICATION
Some principles of organization of spinal neurons underlying locomotion in zebrafish and their implications
- Authors
- Fetcho, J.R., and McLean, D.L.
- ID
- ZDB-PUB-100614-33
- Date
- 2010
- Source
- Annals of the New York Academy of Sciences 1198: 94-104 (Review)
- Registered Authors
- Fetcho, Joseph R.
- Keywords
- motoneurons, spinal interneurons, transcription factors, locomotion, motor pattern
- MeSH Terms
-
- Interneurons/cytology
- Interneurons/physiology
- Zebrafish/physiology*
- Motor Neurons/cytology
- Motor Neurons/physiology
- Spinal Cord/cytology
- Spinal Cord/physiology*
- Neurons/physiology*
- Animals
- Ranidae
- Cell Differentiation
- Locomotion/physiology*
- Chickens
- Species Specificity
- Swimming/physiology
- Nerve Net/physiology
- Electrophysiology
- Motor Activity/physiology
- Mice
- Synaptic Transmission/physiology
- PubMed
- 20536924 Full text @ Ann N Y Acad Sci
Citation
Fetcho, J.R., and McLean, D.L. (2010) Some principles of organization of spinal neurons underlying locomotion in zebrafish and their implications. Annals of the New York Academy of Sciences. 1198:94-104.
Abstract
Recent studies of the spinal motor system of zebrafish, along with work in other species, are leading to some principles that appear to underlie the organization and recruitment of motor networks in cord: (1) broad neuronal classes defined by a set of transcription factors, key morphological features, and transmitter phenotypes arise in an orderly way from different dorso-ventral zones in spinal cord; (2) motor behaviors and both motoneurons and interneurons differentiate in order from gross, often faster, movements and the neurons driving them to progressively slower movements and their underlying neurons; (3) recruitment order of motoneurons and interneurons is based upon time of differentiation; (4) different locomotor speeds involve some shifts in the set of active interneurons. Here we review these principles and some of their implications for other parts of the brain, other vertebrates, and limbed locomotion.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping