PUBLICATION

Pax2 is expressed in a subpopulation of Müller cells in the central chick retina

Authors
Boije, H., Ring, H., López-Gallardo, M., Prada, C., and Hallböök, F.
ID
ZDB-PUB-100601-12
Date
2010
Source
Developmental Dynamics : an official publication of the American Association of Anatomists   239(6): 1858-1866 (Journal)
Registered Authors
Keywords
avascular, development, EdU, glia, Müller glia, regeneration, Sox2, zebrafish
MeSH Terms
  • Animals
  • Cells
  • Chick Embryo
  • D-Aspartic Acid/metabolism
  • Embryo, Nonmammalian
  • N-Methylaspartate/metabolism
  • Neuroglia/metabolism*
  • PAX2 Transcription Factor/metabolism*
  • Retina*/embryology
  • Retina*/metabolism
  • Retina*/physiology
PubMed
20503381 Full text @ Dev. Dyn.
Abstract
Müller cells in the chick retina are generally thought to be a homogeneous population. We show that the transcription factor Pax2 is expressed by Müller cells in the central chick retina and its expression was first observed at stage 32 (embryonic day [E] 7.5). Birth-dating indicated that the majority of Pax2-positive Müller cells are generated between stage 29 and 33 (E5.5-E8). At stage 42 (E16), several Müller cell markers, such as Sox2 and 2M6, had reached the peripheral retina, while the Pax2 labeling extended approximately half-way. A similar pattern was maintained in the 6-month-old chicken. Neither the Pax2-positive nor the Pax2-negative Müller cells could be specifically associated to proliferative responses in the retina induced by growth factors or N-methyl-D-aspartate. Pax2 was not detected in Müller cells in mouse, rat, guinea-pig, rabbit, or pig retinas; but the zebrafish retina displayed a similar pattern of central Pax2-expressing Müller cells.
Genes / Markers
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Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
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Mapping