|ZFIN ID: ZDB-PUB-100601-12|
Pax2 is expressed in a subpopulation of Müller cells in the central chick retina
Boije, H., Ring, H., López-Gallardo, M., Prada, C., and Hallböök, F.
|Source:||Developmental dynamics : an official publication of the American Association of Anatomists 239(6): 1858-1866 (Journal)|
|Keywords:||avascular, development, EdU, glia, Müller glia, regeneration, Sox2, zebrafish|
|PubMed:||20503381 Full text @ Dev. Dyn.|
Boije, H., Ring, H., López-Gallardo, M., Prada, C., and Hallböök, F. (2010) Pax2 is expressed in a subpopulation of Müller cells in the central chick retina. Developmental dynamics : an official publication of the American Association of Anatomists. 239(6):1858-1866.
ABSTRACTMüller cells in the chick retina are generally thought to be a homogeneous population. We show that the transcription factor Pax2 is expressed by Müller cells in the central chick retina and its expression was first observed at stage 32 (embryonic day [E] 7.5). Birth-dating indicated that the majority of Pax2-positive Müller cells are generated between stage 29 and 33 (E5.5-E8). At stage 42 (E16), several Müller cell markers, such as Sox2 and 2M6, had reached the peripheral retina, while the Pax2 labeling extended approximately half-way. A similar pattern was maintained in the 6-month-old chicken. Neither the Pax2-positive nor the Pax2-negative Müller cells could be specifically associated to proliferative responses in the retina induced by growth factors or N-methyl-D-aspartate. Pax2 was not detected in Müller cells in mouse, rat, guinea-pig, rabbit, or pig retinas; but the zebrafish retina displayed a similar pattern of central Pax2-expressing Müller cells.