ZFIN ID: ZDB-PUB-100525-13
Parallel visual cycles in the zebrafish retina
Fleisch, V.C., and Neuhauss, S.C.
Date: 2010
Source: Progress in Retinal and Eye Research   29(6): 476-486 (Review)
Registered Authors: Fleisch, Valerie, Neuhauss, Stephan
Keywords: none
MeSH Terms:
  • Animals
  • Models, Animal
  • Neuroglia/physiology
  • Retina/cytology
  • Retina/physiology*
  • Retinal Cone Photoreceptor Cells/metabolism
  • Retinal Cone Photoreceptor Cells/physiology*
  • Retinaldehyde/metabolism
  • Vision, Ocular/physiology*
  • Visual Pathways/anatomy & histology
  • Visual Pathways/physiology
  • Zebrafish/anatomy & histology*
PubMed: 20488254 Full text @ Prog. Retin. Eye Res.
Vertebrate vision necessitates continuous recycling of the chromophore 11-cis retinal (RAL). The classical (or canonical) visual cycle employs a number of enzymes located in the photoreceptor outer segment and RPE (retinal pigment epithelium) of the retina to regenerate 11-cis RAL from all-trans RAL. Cone-dominant species are believed to utilize a second, intra-retinal, pathway for 11-cis RAL generation, involving retinal Müller glia cells. This review summarizes the efforts made in zebrafish to gain a better understanding of the role of these two visual cycles for rod and cone photoreceptor chromophore recycling.