|ZFIN ID: ZDB-PUB-100525-13|
Parallel visual cycles in the zebrafish retina
Fleisch, V.C., and Neuhauss, S.C.
|Source:||Progress in Retinal and Eye Research 29(6): 476-486 (Review)|
|Registered Authors:||Fleisch, Valerie, Neuhauss, Stephan|
|PubMed:||20488254 Full text @ Prog. Retin. Eye Res.|
Fleisch, V.C., and Neuhauss, S.C. (2010) Parallel visual cycles in the zebrafish retina. Progress in Retinal and Eye Research. 29(6):476-486.
ABSTRACTVertebrate vision necessitates continuous recycling of the chromophore 11-cis retinal (RAL). The classical (or canonical) visual cycle employs a number of enzymes located in the photoreceptor outer segment and RPE (retinal pigment epithelium) of the retina to regenerate 11-cis RAL from all-trans RAL. Cone-dominant species are believed to utilize a second, intra-retinal, pathway for 11-cis RAL generation, involving retinal Müller glia cells. This review summarizes the efforts made in zebrafish to gain a better understanding of the role of these two visual cycles for rod and cone photoreceptor chromophore recycling.
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