PUBLICATION
Making a difference together: reciprocal interactions in C. elegans and zebrafish asymmetric neural development
- Authors
- Taylor, R.W., Hsieh, Y.W., Gamse, J.T., and Chuang, C.F.
- ID
- ZDB-PUB-100223-6
- Date
- 2010
- Source
- Development (Cambridge, England) 137(5): 681-691 (Review)
- Registered Authors
- Taylor, Robert
- Keywords
- C. elegans, Left-right asymmetry, Zebrafish
- MeSH Terms
-
- Animals
- Body Patterning/genetics
- Body Patterning/physiology*
- Brain/embryology*
- Caenorhabditis elegans/embryology*
- Embryo, Nonmammalian
- Functional Laterality/genetics
- Functional Laterality/physiology
- Gap Junctions/genetics
- Gap Junctions/physiology
- Gene Expression Regulation, Developmental
- Models, Biological
- Zebrafish/embryology*
- PubMed
- 20147373 Full text @ Development
Citation
Taylor, R.W., Hsieh, Y.W., Gamse, J.T., and Chuang, C.F. (2010) Making a difference together: reciprocal interactions in C. elegans and zebrafish asymmetric neural development. Development (Cambridge, England). 137(5):681-691.
Abstract
Brain asymmetries are thought to increase neural processing capacity and to prevent interhemispheric conflict. In order to develop asymmetrically, neurons must be specified along the left-right axis, assigned left-side versus right-side identities and differentiate appropriately. In C. elegans and zebrafish, the cellular and molecular mechanisms that lead to neural asymmetries have recently come to light. Here, we consider recent insights into the mechanisms involved in asymmetrical neural development in these two species. Although the molecular details are divergent, both organisms use iterative cell-cell communication to establish left-right neuronal identity.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping