PUBLICATION

Neuronal Regulation of the Spatial Patterning of Neurogenesis

Authors
Gonzalez-Quevedo, R., Lee, Y., Poss, K.D., and Wilkinson, D.G.
ID
ZDB-PUB-100223-14
Date
2010
Source
Developmental Cell   18(1): 136-147 (Journal)
Registered Authors
Lee, Yoonsung, Poss, Kenneth D., Wilkinson, David
Keywords
DEVBIO, MOLNEURO
MeSH Terms
  • Animals
  • Body Patterning/physiology*
  • Cell Communication/physiology
  • Cytochrome P-450 Enzyme System/genetics
  • Cytochrome P-450 Enzyme System/metabolism
  • DNA-Binding Proteins/genetics
  • DNA-Binding Proteins/metabolism
  • Fibroblast Growth Factor 2/metabolism
  • Fibroblast Growth Factors/genetics
  • Fibroblast Growth Factors/metabolism
  • Gene Expression Regulation, Developmental/physiology
  • Neurogenesis/physiology*
  • Neurons/cytology
  • Neurons/metabolism*
  • Rhombencephalon/cytology
  • Rhombencephalon/embryology*
  • Rhombencephalon/metabolism*
  • SOX9 Transcription Factor/genetics
  • SOX9 Transcription Factor/metabolism
  • Signal Transduction/physiology
  • Stem Cells/cytology
  • Stem Cells/metabolism*
  • Transcription Factors/genetics
  • Transcription Factors/metabolism
  • Zebrafish
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed
20152184 Full text @ Dev. Cell
Abstract
Precise regulation of neurogenesis is achieved in specific regions of the vertebrate nervous system by formation of distinct neurogenic and nonneurogenic zones. We have investigated how neurogenesis becomes confined to zones adjacent to rhombomere boundaries in the zebrafish hindbrain. The nonneurogenic zone at segment centers comprises a distinct progenitor population that expresses fibroblast growth factor (fgfr) 2, erm, sox9b, and the retinoic acid degrading enzyme, cyp26b1. FGF receptor activation upregulates expression of these genes and inhibits neurogenesis in segment centers. Cyp26 activity is a key effector inhibiting neuronal differentiation, suggesting antagonistic interactions with retinoid signaling. We identify the critical FGF ligand, fgf20a, which is expressed by specific neurons located in the mantle region at the center of segments, adjacent to the nonneurogenic zone. Fgf20a mutants have ectopic neurogenesis and lack the segment center progenitor population. Our findings reveal how signaling from neurons induces formation of a nonneurogenic zone of neural progenitors.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes