ZFIN ID: ZDB-PUB-090921-30
Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway
Roszko, I., Sawada, A., and Solnica-Krezel, L.
Date: 2009
Source: Seminars in cell & developmental biology   20(8): 986-997 (Review)
Registered Authors: Sawada, Atsushi, Solnica-Krezel, Lilianna
Keywords: Gastrulation, Zebrafish, Planar Cell Polarity (PCP), Convergence and extension, Non-canonical Wnt
MeSH Terms:
  • Animals
  • Cell Movement
  • Cell Polarity*
  • Gastrulation*
  • Humans
  • Signal Transduction*
  • Vertebrates/embryology*
  • Vertebrates/metabolism*
  • Wnt Proteins/metabolism*
PubMed: 19761865 Full text @ Sem. Cell Dev. Biol.
ABSTRACT
Vertebrate gastrulation entails massive cell movements that establish and shape the germ layers. During gastrulation, the individual cell behaviors are strictly coordinated in time and space by various signaling pathways. These pathways instruct the cells about proliferation, shape, fate and migration into proper location. Convergence and extension (C&E) movements during vertebrate gastrulation play a major role in the shaping of the embryonic body. In vertebrates, the Wnt/Planar Cell Polarity (Wnt/PCP) pathway is a key regulator of C&E movements, essential for several polarized cell behaviors, including directed cell migration, and mediolateral and radial cell intercalation. However, the molecular mechanisms underlying the acquisition of planar cell polarity by highly dynamic mesenchymal cells engaged in C&E is still not well understood. Each cell in the embryo needs spatial and temporal information, which are required for its appropriate behavior, and the Wnt/PCP pathway provides this information by a yet unclear mechanism. Here we review new evidence implicating the Wnt/PCP pathway in specific cell behaviors required for C&E during zebrafish gastrulation, in comparison to other vertebrates. We also discuss findings on the molecular regulation and the interaction of the Wnt/PCP pathway with other signaling pathways during gastrulation movements.
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