PUBLICATION
Genetic dissection of myelinated axons in zebrafish
- Authors
- Monk, K.R., and Talbot, W.S.
- ID
- ZDB-PUB-090914-43
- Date
- 2009
- Source
- Current opinion in neurobiology 19(5): 486-490 (Review)
- Registered Authors
- Monk, Kelly, Talbot, William S.
- Keywords
- none
- MeSH Terms
-
- Animals
- Axons/physiology*
- Genetic Techniques
- Models, Genetic
- Myelin Sheath/genetics*
- Myelin Sheath/physiology*
- Nerve Fibers, Myelinated/physiology*
- Neuroglia/physiology
- Zebrafish/genetics*
- Zebrafish/physiology*
- PubMed
- 19740648 Full text @ Curr. Opin. Neurobiol.
Citation
Monk, K.R., and Talbot, W.S. (2009) Genetic dissection of myelinated axons in zebrafish. Current opinion in neurobiology. 19(5):486-490.
Abstract
In the vertebrate nervous system, the myelin sheath allows for rapid and efficient conduction of action potentials along axons. Despite the essential function of myelin, many questions remain unanswered about the mechanisms that govern the development of myelinated axons. The fundamental properties of myelin are widely shared among vertebrates, and the zebrafish has emerged as a powerful system to study myelination in vivo. This review will highlight recent advances from genetic screens in zebrafish, including the discovery of the role of kif1b in mRNA localization in myelinating oligodendrocytes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping