ZFIN ID: ZDB-PUB-090914-42
Convergence and extension movements during vertebrate gastrulation
Yin, C., Ciruna, B., and Solnica-Krezel, L.
Date: 2009
Source: Current topics in developmental biology   89: 163-192 (Review)
Registered Authors: Ciruna, Brian, Solnica-Krezel, Lilianna, Yin, Chunyue
Keywords: Bmp, Directed migration, G protein, Intercalation, Mesoderm, Noncanonical Wnt signalling, Oriented cell division, Planar cell polarity, Stat3, Zebrafish
MeSH Terms:
  • Animals
  • Cell Movement*
  • Cell Polarity
  • Gastrulation/physiology*
  • Mesoderm/cytology
  • Time Factors
  • Vertebrates/embryology*
PubMed: 19737646 Full text @ Curr. Top. Dev. Biol.
During vertebrate gastrulation, coordinated cell movements shape the basic body plan. Key components of gastrulation are convergence and extension (C&E) movements, which narrow and lengthen the embryonic tissues, respectively. The rates of C&E movements differ significantly according to the position and the stage of gastrulation. Here, we review the distinct cellular behaviors that define the spatial and temporal patterns of C&E movements, with the special emphasis on zebrafish. We also summarize the molecular regulation of these cellular behaviors and the interplay between different signaling pathways that drive C&E. Finally, to ensure efficient C&E movements, cells must achieve mediolaterally-elongated cell morphology and polarize motile protrusions. We discuss the recent discoveries on the molecular and cellular mechanisms by which the mediolateral cell polarity is established.