PUBLICATION

Zebrafish cyp11a1 and hsd3b Genes: Structure, Expression and Steroidogenic Development during Embryogenesis

Authors
Hsu, H.J., Lin, J.C., and Chung, B.C.
ID
ZDB-PUB-090819-5
Date
2009
Source
Molecular and cellular biology   312(1-2): 31-34 (Review)
Registered Authors
Chung, Bon-chu
Keywords
Steroidogenesis, Adrenal, Head kidney, Embryogenesis, Gastrulation
MeSH Terms
  • 3-Hydroxysteroid Dehydrogenases/chemistry
  • 3-Hydroxysteroid Dehydrogenases/genetics*
  • Animals
  • Cholesterol Side-Chain Cleavage Enzyme/chemistry
  • Cholesterol Side-Chain Cleavage Enzyme/genetics*
  • Gastrulation/genetics
  • Gene Expression Regulation, Developmental
  • Genomics/methods
  • Kidney/embryology
  • Kidney/enzymology
  • Kidney/metabolism
  • Models, Animal
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish/metabolism
  • Zebrafish Proteins/chemistry
  • Zebrafish Proteins/genetics*
PubMed
19682541 Full text @ Mol. Cell. Biol.
Abstract
Zebrafish has been used increasingly as a good animal model for a number of studies. To facilitate the use of this zebrafish model, the current report put emphasis on the study of two steroidogenic genes: cyp11a1 and hsd3b. These two genes encode enzymes that catalyze the first two steps of the steroidogenic pathway, and both enzymes are important for the synthesis of all steroids. Zebrafish cyp11a1 and hsd3b genes are expressed in the same cells in the gonads and interrenal gland. The interrenal gland is the counterpart of mammalian adrenal; it is located inside the head kidney and is developed parallel to the development of the pronephros. In addition, cyp11a1 and hsd3b are also expressed in the blastomeres of the early embryos before gastrulation, and in the extra-embryonic yolk syncytial layer during gastrulation. This early expression implies a novel role of steroids at gastrulation.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Errata and Notes