PUBLICATION
Induction of estrogen-responsive gene transcription in the embryo, larval, juvenile and adult life stages of zebrafish as biomarkers of short-term exposure to endocrine disrupting chemicals
- Authors
- Jin, Y., Chen, R., Sun, L., Qian, H., Liu, W., and Fu, Z.
- ID
- ZDB-PUB-090706-1
- Date
- 2009
- Source
- Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 150(3): 414-420 (Journal)
- Registered Authors
- Keywords
- zebrafish, developmental stages, endocrine disruption, gene expression
- MeSH Terms
-
- Animals
- Biomarkers/analysis*
- Embryo, Nonmammalian/drug effects
- Embryo, Nonmammalian/metabolism*
- Endocrine Disruptors/pharmacology*
- Estradiol/pharmacology
- Estrogens/pharmacology*
- Gene Expression Regulation, Developmental/drug effects*
- Larva/drug effects
- Larva/growth & development
- Larva/metabolism*
- Male
- Phenols/pharmacology
- Reverse Transcriptase Polymerase Chain Reaction
- Vitellogenins/biosynthesis*
- Zebrafish/genetics*
- Zebrafish/growth & development*
- Zebrafish Proteins/genetics
- PubMed
- 19559814 Full text @ Comp. Biochem. Physiol. C Toxicol. Pharmacol.
Citation
Jin, Y., Chen, R., Sun, L., Qian, H., Liu, W., and Fu, Z. (2009) Induction of estrogen-responsive gene transcription in the embryo, larval, juvenile and adult life stages of zebrafish as biomarkers of short-term exposure to endocrine disrupting chemicals. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 150(3):414-420.
Abstract
Real-time quantitative RT-PCR was adopted to investigate the transcription of the estrogen-responsive genes in different developmental stages of zebrafish exposed to endocrine disrupting chemicals (EDCs). The lowest observed effect concentrations (LOECs) of 17beta-estradiol for inducing vtg1 transcription were 0.25, 0.5, 0.25 and
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping