|ZFIN ID: ZDB-PUB-090616-54|
Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling
Tee, J.M., van Rooijen, C., Boonen, R., and Zivkovic, D.
|Source:||PLoS One 4(6): e5880 (Journal)|
|Registered Authors:||van Rooijen, Carina|
|Keywords:||Embryos, Muscle fibers, Muscle differentiation, Somites, Fast-twitch muscle fibers, Slow-twitch muscle fibers, Wnt signaling cascade, Zebrafish|
|PubMed:||19517013 Full text @ PLoS One|
Tee, J.M., van Rooijen, C., Boonen, R., and Zivkovic, D. (2009) Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling. PLoS One. 4(6):e5880.
ABSTRACTDeviation from proper muscle development or homeostasis results in various myopathic conditions. Employing genetic as well as chemical intervention, we provide evidence that a tight regulation of Wnt/beta-catenin signaling is essential for muscle fiber growth and maintenance. In zebrafish embryos, gain-of-Wnt/beta-catenin function results in unscheduled muscle progenitor proliferation, leading to slow and fast muscle hypertrophy accompanied by fast muscle degeneration. The effects of Wnt/beta-catenin signaling on fast muscle hypertrophy were rescued by misexpression of Myostatin or p21(CIP/WAF), establishing an in vivo regulation of myofibrillogenesis by Wnt/beta-catenin signaling and Myostatin. Epistatic analyses suggest a possible genetic interaction between Wnt/beta-catenin and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis.