PUBLICATION
Conserved recoding RNA editing of vertebrate C1q-related factor C1QL1
- Authors
- Sie, C.P., and Maas, S.
- ID
- ZDB-PUB-090318-7
- Date
- 2009
- Source
- FEBS letters 583(7): 1171-1174 (Journal)
- Registered Authors
- Keywords
- RNA editing, Inosine, Adenosine deaminase acting on RNA, Double-stranded RNA, Complement component 1, q subcomponent-like 1, Single-nucleotide polymorphism
- MeSH Terms
-
- Amino Acid Substitution*
- Animals
- Complement C1q/genetics*
- Humans
- Membrane Glycoproteins/genetics*
- Mice
- Nucleic Acid Conformation
- Polymorphism, Single Nucleotide
- RNA Editing/physiology*
- RNA Precursors/genetics*
- Receptors, Complement/genetics*
- Zebrafish/genetics*
- PubMed
- 19275900 Full text @ FEBS Lett.
Citation
Sie, C.P., and Maas, S. (2009) Conserved recoding RNA editing of vertebrate C1q-related factor C1QL1. FEBS letters. 583(7):1171-1174.
Abstract
A-to-I RNA editing can lead to recoding of pre-mRNAs with profound functional consequences for the ensuing proteins. Here we show that complement component 1, q subcomponent-like 1 (C1QL1) undergoes RNA editing in vivo causing non-synonymous amino acid substitutions in human, mouse as well as zebrafish. The major editing site had previously been annotated as a single-nucleotide polymorphism in human, but our analysis reveals that post-transcriptional modification is the cause for the sequence variation. Remarkably, although editing of C1QL1 is conserved across vertebrate species, the predicted RNA secondary structure mediating editing involves different regions in zebrafish versus mammals.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping