PUBLICATION
The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications
- Authors
- Dejana, E., Tournier-Lasserve, E., and Weinstein, B.M.
- ID
- ZDB-PUB-090217-40
- Date
- 2009
- Source
- Developmental Cell 16(2): 209-221 (Review)
- Registered Authors
- Weinstein, Brant M.
- Keywords
- none
- MeSH Terms
-
- Cadherins/metabolism
- Antigens, CD/metabolism
- Humans
- Cyclic AMP/metabolism
- Animals
- Mice
- Intercellular Junctions/metabolism
- Models, Biological
- Phenotype
- rap1 GTP-Binding Proteins/metabolism
- Mice, Transgenic
- Endothelium, Vascular/pathology*
- Disease Models, Animal
- Capillary Permeability
- Binding Sites
- Signal Transduction
- PubMed
- 19217423 Full text @ Dev. Cell
Citation
Dejana, E., Tournier-Lasserve, E., and Weinstein, B.M. (2009) The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications. Developmental Cell. 16(2):209-221.
Abstract
Human pathologies such as vascular malformations, hemorrhagic stroke, and edema have been associated with defects in the organization of endothelial cell junctions. Understanding the molecular basis of these diseases requires different integrated approaches which include basic cell biology, clinical studies, and studies in animal models such as mice and zebrafish. In this review we discuss recent findings derived from these approaches and their possible integration in a common picture.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping