PUBLICATION
Oxidative stress and structure-activity relationship in the zebrafish (Danio rerio) under exposure to paclobutrazol
- Authors
- Ding, F., Song, W.H., Guo, J., Gao, M.L., and Hu, W.X.
- ID
- ZDB-PUB-081218-40
- Date
- 2009
- Source
- Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 44(1): 44-50 (Journal)
- Registered Authors
- Hu, Wei
- Keywords
- Paclobutrazol, zebrafish, acute toxicity, oxidative stress, SAR
- MeSH Terms
-
- Animals
- Antioxidants/metabolism*
- Catalase/metabolism
- Oxidative Stress/drug effects*
- Structure-Activity Relationship
- Superoxide Dismutase/metabolism
- Time Factors
- Toxicity Tests, Acute
- Triazoles/chemistry*
- Triazoles/metabolism
- Triazoles/toxicity*
- Zebrafish/metabolism*
- PubMed
- 19089714 Full text @ J. Environ. Sci. Health B
Citation
Ding, F., Song, W.H., Guo, J., Gao, M.L., and Hu, W.X. (2009) Oxidative stress and structure-activity relationship in the zebrafish (Danio rerio) under exposure to paclobutrazol. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 44(1):44-50.
Abstract
The acute toxicity and changes in the activity of antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT) in the zebrafish Danio rerio were measured when the fish was exposed to paclobutrazol (PBZ) under laboratory conditions. The median lethal concentration value at 96 h post-exposure (LC(50) (96 h)) was determined to be 20.55 mg/L. In addition, the SOD activities in D. rerio were significantly higher at 96 h post-exposure among the various concentrations of the pollutant tested. The change of CAT activity could be considered as a sensitive biomarker of the oxidative stress induced by PBZ. The structure-activity relationship (SAR) analysis identified the potential active points for the pollutant and that the cavum may be the site of interaction with the receptor.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping