PUBLICATION
Role of p53 family in birth defects: Lessons from zebrafish
- Authors
- Danilova, N., Sakamoto, K.M., and Lin, S.
- ID
- ZDB-PUB-080908-17
- Date
- 2008
- Source
- Birth defects research. Part C, Embryo today : reviews 84(3): 215-227 (Review)
- Registered Authors
- Danilova, Nadia, Lin, Shuo
- Keywords
- zebrafish, p53, p63, p73, congenital abnormalities
- MeSH Terms
-
- Animals
- Congenital Abnormalities/genetics*
- Embryo, Nonmammalian/abnormalities*
- Embryo, Nonmammalian/metabolism
- Embryo, Nonmammalian/radiation effects
- Gene Expression Regulation, Developmental/genetics
- Gene Expression Regulation, Developmental/radiation effects
- Protein Isoforms/genetics
- Protein Isoforms/metabolism
- Tumor Suppressor Protein p53/genetics
- Tumor Suppressor Protein p53/metabolism*
- Zebrafish/embryology
- Zebrafish/genetics
- Zebrafish/metabolism*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 18773461 Full text @ Birth Defects Res. C Embryo Today
Citation
Danilova, N., Sakamoto, K.M., and Lin, S. (2008) Role of p53 family in birth defects: Lessons from zebrafish. Birth defects research. Part C, Embryo today : reviews. 84(3):215-227.
Abstract
p53 protein family is an important teratologic suppressor, but in certain conditions it can cause congenital abnormalities. p53 family performs this dual role in development by integrating information from cell's interior with that from the environment to determine the choice between life and death. Understanding of p53 family developmental functions may lead to new therapeutic approaches for treatment and prevention of birth defects. Zebrafish is becoming the vertebrate system of choice for studying p53 family role in development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping