A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia
- England, S.J., Blanchard, G.B., Mahadevan, L., and Adams, R.J.
- Development (Cambridge, England) 133(23): 4613-4617 (Journal)
- Registered Authors
- Adams, Richard
- Zebrafish, Time-lapse microscopy, Neurulation, Cyclopia, Quantitative analyses
- MeSH Terms
- Eye Abnormalities/embryology*
- Eye Abnormalities/genetics
- Intracellular Signaling Peptides and Proteins/genetics
- Wnt Proteins/genetics
- Zebrafish Proteins/genetics
- 17079266 Full text @ Development
England, S.J., Blanchard, G.B., Mahadevan, L., and Adams, R.J. (2006) A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia. Development (Cambridge, England). 133(23):4613-4617.
Mechanisms for shaping and folding sheets of cells during development are poorly understood. An example is the complex reorganisation of the forebrain neural plate during neurulation, which must fold a sheet into a tube while evaginating two eyes from a single contiguous domain within the neural plate. We, for the first time, track these cell rearrangements to show that forebrain morphogenesis differs significantly from prior hypotheses. We postulate a new model for forebrain neurulation and demonstrate how mutations affecting two signalling pathways can generate cyclopic phenotypes by disrupting normal cell movements or introducing new erroneous behaviours.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes