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ZFIN ID: ZDB-PUB-080722-4
Spatio-temporal expression patterns of anterior Hox genes in Atlantic salmon (Salmo salar)
Mungpakdee, S., Seo, H.C., and Chourrout, D.
Date: 2008
Source: Gene expression patterns : GEP   8(7-8): 508-514 (Journal)
Registered Authors: Chourrout, Daniel, Seo, Hee-Chan
Keywords: Hox gene, genome duplication, teleost, subfunctionalization, pseudogene
MeSH Terms:
  • Animals
  • Gene Duplication
  • Gene Expression
  • Genes, Homeobox*
  • Phylogeny
  • Salmo salar/genetics*
  • Time Factors
PubMed: 18620079 Full text @ Gene Expr. Patterns
Hox genes encode transcription factors that play important roles in patterning the anterior-posterior (A-P) body axis. In vertebrates, up to 14 Hox genes are physically linked in 4-13 chromosomal clusters. Their expression patterns obey spatial and temporal collinearity. Genes located at the 3' end of the clusters are expressed earlier and more anteriorly than those at the 5' end. To investigate how the expression of Hox genes has evolved after very recent ( approximately 25-100Mya) and relatively recent ( approximately 320-350Mya) genome duplications, we focused on three paralogous groups of salmon anterior Hox genes, in which gene duplicates have been retained. RNA-RNA whole mount in situ hybridization with gene-specific probes at early development stages showed essentially conserved expression patterns for most genes when compared to mouse and zebrafish orthologs. However, changes in spatial expression were observed for the ancient fish gene duplicate HoxB3b, while recently duplicated genes showed divergence in their expression levels.