ZFIN ID: ZDB-PUB-080429-3
Molecular and developmental biology of the hemangioblast
Xiong, J.W.
Date: 2008
Source: Developmental dynamics : an official publication of the American Association of Anatomists   237(5): 1218-1231 (Review)
Registered Authors: Xiong, Jing-Wei
Keywords: hemangioblast, angioblasts, hematopoietic cells, mouse embryonic stem cells, human embryonic stem cells, developmental biology, zebrafish, chick, mouse
MeSH Terms:
  • Animals
  • Embryonic Stem Cells/cytology
  • Embryonic Stem Cells/physiology
  • Gastrula/cytology
  • Hematopoietic Stem Cells*/cytology
  • Hematopoietic Stem Cells*/physiology
  • Humans
  • Vascular Endothelial Growth Factor A/genetics
  • Vascular Endothelial Growth Factor A/metabolism
  • Vascular Endothelial Growth Factor Receptor-2/genetics
  • Vascular Endothelial Growth Factor Receptor-2/metabolism
PubMed: 18429046 Full text @ Dev. Dyn.
The hemangioblast hypothesis was proposed a century ago. The existence of hemangioblasts is now demonstrated in mouse and human embryonic stem cell (ESC) -derived embryoid bodies (EBs), in the mouse and zebrafish gastrula, and in adults. The hemangioblast is believed to derive from mesodermal cells, and is enriched in the Bry(+)Flk1(+) and Flk1(+)Scl(+) cell populations in EBs and in the posterior primitive streak of the mouse gastrula and in the ventral mesoderm of the zebrafish gastrula. However, recent studies suggest that the hemangioblast does not give rise to all endothelial and hematopoietic lineages in mouse and zebrafish embryos. Although several signaling pathways are known to involve the generation of hemangioblasts, it remains largely unknown how the hemangioblast is formed and what are the master genes controlling hemangioblast development. This review will summarize our current knowledge, challenges, and future directions on molecular and developmental aspects of the hemangioblast.